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Scientific Publications 2017-01-20T21:13:12+00:00

Scientific Publications

Oral Aspirin and Ibuprofen Increase Cytokine-Induced Synthesis of IL-1β and of Tumour Necrosis Factor-αex Vivo

We investigated the effect of oral aspirin and ibuprofen on the ex vivo synthesis of interleukin-1α (IL-1α), IL-1β, IL-2, IL-6, tumour necrosis factor-α (TNF) and granulocyte–macrophage colony-stimulating factor (GM-CSF) by stimulated peripheral blood mononuclear cells (PBMC) from healthy volunteers.
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Correlations and Interactions in the Production of Interleukin-6 (IL- 6), IL-1, and Tumor Necrosis Factor (TNF) in Human Blood Mononuclear Cells: IL-6 Suppresses IL-1 and TNF

Interleukin-6 (IL-6) shares several biologic properties with IL-1, including hematopoietin-1 activity and stimulation of T cells. Because many of their biologic activities overlap, we developed and used a specific radioimmunoassay (RIA) for IL-6 to compare production of this cytokine on a molar basis with that of IL-1 alpha, IL-1 beta, and tumor necrosis factor (TNF)alpha. The RIA correlated well with the hybridoma bioassay for IL-6 (r = .87, P less than .001).
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In Vitro Production of IL 1β, IL 1α, TNF and IL 2 in Healthy Subjects: Distribution, Effect of Cyclooxygenase Inhibition and Evidence of Independent Gene Regulation

Numerous studies have reported altered in vitro cytokine production in various diseases. In the present study we used specific immunoassays to quantitate production of interleukin 1β (IL 1β), IL 1α, tumor necrosis factor (TNF) and IL 2 from human peripheral blood mononuclear cells (PBMC).
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The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

We examined whether the synthesis of interleukin-1 or tumor necrosis factor, two cytokines with potent inflammatory activities, is influenced by dietary supplementation with n—3 fatty acids.
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Measurement of Immunoreactive Interleukin-1β from Human Mononuclear Cells: Optimization of Recovery, Intrasubject Consistency, and Comparison with Interleukin-1α and Tumor Necrosis Factor

Numerous studies have reported altered levels of in vitro production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF) from blood leukocytes in various human disease states. Most of these studies have used bioassays which are vulnerable to inhibitors produced by these cells. Furthermore in vitrocytokine production is often assessed on a single occasion.
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